TELOMERASE INHIBITORS AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2012 - IPC C07F1/08 A61K31/30 

FIELD: chemistry.

SUBSTANCE: invention relates to novel coordination compounds - imidazol-4-one derivatives, which inhibit telomerase, of general formula , where substitute A is selected from a group comprising aryl substitutes, condensed aryl substitutes, cyclopentyl, cyclohexyl, aliphatic substitutes, aliphatic substitutes with a double bond, aliphatic substitutes with a triple bond, a methylamine substitute CH₃NH-, a carbethoxy group C₂H₅O(O)C-, five-member heterocyclic substitutes with one nitrogen atom, five-member heterocyclic substitutes with two nitrogen atoms, six-member heterocyclic substitutes, substitute B is absent or is an aliphatic substitute, substitute C is a heteroaryl substitute bonded to the imidazol-4-one derivative through a carbon atom and is selected from a group comprising 5-member unsaturated monocyclic heteroaryl substitutes with 1, 2 or 3 heteroatoms in a ring, selected from a group comprising N, O and S, 6-member unsaturated monocyclic heteroaryl substitutes with 1, 2 or 3 heteroatoms in a ring, selected from a group comprising N, O and S, 8-, 9- and 10-member unsaturated bicyclic heteroaryl substitutes with 1, 2 or 3 heteroatoms in a ring, selected from a group comprising N, O and S, X is a chloride Cl or nitrate NO₃. A method of producing said compounds is also provided.

EFFECT: invention enables to obtain novel imidazol-4-one derivatives capable of inhibiting telomerase.

8 cl, 5 dwg, 2 tbl, 24 ex