NOVEL ARYL-THIOHYDANTOIN DERIVATIVES, ANDROGEN RECEPTOR INHIBITORS, METHOD OF PRODUCING AND USING THEREOF Russian patent published in 2019 - IPC C07D233/86 A61K31/4166 A61K31/4174 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to derivatives of S-5-arylidene-2-(arylthio)-3,5-dihydro-4H-imidazol-4-one of formulas 1 or 2, where R₁ is a substitute selected from a hydrogen atom, a halogen atom, a methoxy group, a cyano group; R₂ is a substituent selected from a hydrogen atom, a halogen atom; R₃ a substitute selected from a hydrogen atom, a halogen atom, a methoxy group; R₄ a substitute selected from a hydrogen atom, a halogen atom, a methoxy group; R₅ - phenyl substituted with 1 substitute selected from halogen atom, lower alkoxy group. Invention also relates to a method of producing a compound of formula 1 or 2, a pharmaceutical composition and a medicinal agent based on a compound of formula 1 or 2.

EFFECT: technical result is obtaining novel heterocyclic compounds useful for preventing and treating oncological disease associated with androgen receptor activity.

15 cl, 2 dwg, 1 tbl, 25 ex