GEL-FORMING MIXED DEXTRAN ESTER PHOSPHATES AND CARBAMATES, METHOD FOR PREPARING THEM Russian patent published in 2012 - IPC A61K31/721 A61K31/17 A61K9/52 A61K33/42 A61K49/12 A61P35/00 C08B37/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine and represents gel-forming mixed dextran esters containing phosphate and carbamate groups of general formula: {C₆H₇O₂(OH)_3-x-y{[(OP(O)ONa)_mONa)]_xl[(O₂P(O)ONa)_k]x₂}_x(OCONH₂)_y}_n, wherein x=x₁+x₂ is a degree of substitution in phosphate groups (mono- and diesters), x=0.47-1.09; X₁ is a degree of substitution in monoesters, X₁=0.01-0.48; m is a number of phosphates in monoesters, m=1-2; x₂ is a degree of substitution in diesters, x₂=0.01-1.09; k is a number of phosphates in diesters, k=1-2; y is a degree of substitution in carbamate groups, y=0.39-1.23; n is a degree of polymerisation, 20≥n≤1000.

EFFECT: invention provides producing low-toxic low- and high-substituted dextran phosphates in the form of hydrogels containing additionally carbamate groups and possessing antiproliferative activity with respect to cancer cells.

2 cl, 3 dwg, 14 ex