METHOD FOR PRODUCING GEL-FORMING DEXTRANE PHOSPHATES Russian patent published in 2012 - IPC A61K31/721 C08B37/02 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, medicine, biotechnology, and concerns a method for producing dextrane phosphate hydrogels which can find application in preparing prolonged preparations for treating oncological diseases, infectious diseases, immune disorders. The declared invention describes the method for producing polysaccharide phosphate hydrogels, involving processing of an initial polysaccharide in mixed orthophosphoric acid and phosphorus oxide (V) in an organic solvent medium in the presence of trialkylphosphate at temperature 30-70°C that is followed by washing of the prepared products, drying and processing in an aqueous solution of a mineral compound with the etherification process of dextrane conducted in a non-polar organic solvent medium of the low boiling point specified in hydrocarbons and their derivatives and processing of the prepared product in 0.005-0.5 M aqueous solutions of sodium carbonate, or sodium hydrocarbonate, or sodium hydroxide, or their mixtures to the value pH 3.0-8.0 to be set down in ethanol and dried at temperature 20-50°C.

EFFECT: invention allows producing dextrane phosphate characterised by high pharmacological activity indices.

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