CONTROLLED RELEASE DOSAGE FORMS AND RELATED METHODS Russian patent published in 2012 - IPC A61K31/485 A61K31/167 A61P5/04 A61P9/00 A61K9/22 

FIELD: medicine.

SUBSTANCE: present invention refers to medicine and describes prolonged release therapeutic tablets for oral administration containing a first layer including a first active substance with the first layer arranged between the two adjoining controlled release layers with at least one of said adjoining layers containing at least one second active substance containing acetaminophen with the two adjoining layers enclosed in substantially integrally whole first layer around an external border wherein said tablet provides the applied serum concentration of acetaminophen T_max from approximately 2 hours to approximately 8 hours after administered in a subject. What is also described is the therapeutic tablet wherein the first layer is provided between the two adjoining controlled release layers combined in one continuous layer. There are described methods for controlling drug release.

EFFECT: invention provides preparing the prolonged release composition of simple formulation and structure which can effectively integrate a number of active substances in a stable state and which can provide effective combination drug-induced treatment over a long periods of time.

44 cl, 10 dwg, 9 tbl, 7 ex