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2 664 804

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IPC

C07C255/31(2006-01-01)

C07J63/00(2006-01-01)

A61K31/277(2006-01-01)

A61K31/56(2006-01-01)

A61P31/12(2006-01-01)

A61P31/22(2006-01-01)

(21) (22)

Application

2017113815, 2017-04-20

(24)

Start date

2017-04-20

(22)

Actual filing date

2017-04-20

(45)

Published

2018-08-22

(72)

Inventor

Igosheva Ekaterina ViktorovnaEremin Vladimir FedorovichBoreko Evgenij IvanovichSavinova Olga VladimirovnaTolmacheva Irina AnatolevnaGrishko Viktoriya Viktorovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Permskij Federalnyj Issledovatelskij Tsentr Uralskogo Otdeleniya Rossijskoj Akademii Nauk Uro Ran)

TRITERPENE LUPANE-TYPE AMIDES WITH FRAGMENT OF 2-AMINOBUTAN-1-OL EXHIBITING VIRUS-INHIBITING AND VIRUCIDAL ACTIVITY Russian patent published in 2018 - IPC C07C255/31 C07J63/00 A61K31/277 A61K31/56 A61P31/12 A61P31/22

Abstract RU 2664804 C1

FIELD: chemistry.

SUBSTANCE: invention relates to lupane and 2,3-seco-lupane C28 amides with fragment of 2-aminobutan-1-ol of general formula:

in which R¹=(R)-(-)-2-butan-1-ol, or R¹=(S)-(+)-2-butan-1-ol, or R¹=(R,S)-(+/-)-2-butan-1-ol, or R¹=(R)-(-)-2-butan-1-ol, or R¹=(S)-(+)-2-butan-1-ol, or R¹=(R,S)-(+/-)-2-butan-1-ol, or R¹=(R)-(-)-2-butan-1-ol, or R¹=(S)-(+)-2-butan-1-ol, or R¹=(R,S)-(+/-)-2-butan-1-ol.

EFFECT: new chemical compounds of lupane triterpenoids class, exhibiting virus-inhibiting activity against herpes simplex virus type I (HSV-1), are obtained, and/or virucidal activity against herpes simplex virus type I (HSV-1) or against HIV-1.

4 cl, 3 tbl, 13 ex

или - or

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RU 2 664 804 C1

Authors

Igosheva Ekaterina Viktorovna

Eremin Vladimir Fedorovich

Boreko Evgenij Ivanovich

Savinova Olga Vladimirovna

Tolmacheva Irina Anatolevna

Grishko Viktoriya Viktorovna

Dates

2018-08-22—Published

2017-04-20—Filed