TRANSNASAL PHARMACEUTICAL COMPOSITION Russian patent published in 2012 - IPC A61K47/42 A61K38/17 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, particularly a pharmaceutical composition for nasal introduction containing a hydrophilic biologically active substance and a peptide (a) having an amino acid sequence SEQ ID No:1 N0:1. (b) a peptide having the same amino acid sequence as shown in SEQ ID No:1, except that one or more amino acids are eliminated, substituted and/or added wherein the peptide is penetrable through nasal mucosa, (c) a peptide having an amino acid presented by a sequence reverse in relation to (a) or (b) wherein the peptide is penetrable through nasal mucosa; any of (a)-(c) provided the C-amidated peptide is eliminated. The hydrophilic biologically active substance is poorly absorbable through nasal mucosa which is commonly yet injectable, may be introduced nasally with the use of the declared peptide, particularly insulin or interferon beta.

EFFECT: invention provides injection-associated pain management and lower discomfort in the patients ensured by the nasal introduction of the composition.

7 cl, 5 ex, 8 dwg