FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to biopharmacology and represents a composition, a method and a set, which include a single-chain antibody scFv and a penetration-enhancing substance, selected from amino acid sequences, with a peptide being bound with a protective group with N-terminus, and the penetration-enhancing substance facilitates delivery of large macromolecules (i.e. larger than 10 kDa) through intercellular contacts.
EFFECT: group of inventions provides delivery of therapeutic antigen-binding polypeptides into CNS by intranasal introduction for treatment of neurological disorders.
8 cl, 14 dwg, 8 tbl, 4 ex
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|
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|
RU2826051C2 |
| BISPECIFIC ANTIGEN-BINDING POLYPEPTIDES | 2015 |
|
RU2723940C2 |
