FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology and represents a cell-penetrating peptide for enhancing the passage of a hydrophilic physiologically active substance through a layer of mucosal epitheliocytes, as well as a pharmaceutical composition containing the above peptide. The cell-penetrating peptide represents a peptide with an amino acid sequence presented by SEQ ID NO: 1, as well as a peptide with an amino acid sequence presented by SEQ ID NO: 1, and having various modification; the peptide is able for penetrating through the cell membrane.
EFFECT: invention enables enhancing the passage of the hydrophilic physiologically active substance through the layer of mucosal epitheliocytes and making the hydrophilic physiologically active substance flow into the general circulation.
8 cl, 16 dwg, 1 tbl, 12 ex
