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2 473 553

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IPC

C07F15/06(2006-01-01)

A61K31/295(2006-01-01)

(21) (22)

Application

2011148117/04, 2011-11-25

(24)

Start date

2011-11-25

(22)

Actual filing date

2011-11-25

(45)

Published

2013-01-27

(72)

Inventor

Trofimov Boris AleksandrovichGusarova Nina Kuz'MinichnaShantrokha Aleksandr ViktorovichParshina Lidija NikiforovnaKhil'Ko Marina JakovlevnaGrishchenko Ljudmila Anatol'Evna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Irkutskij Institut Khimii Im. A.E.Favorskogo Sibirskogo Otdelenija Rossijskoj Akademii Nauk

METHOD FOR PRODUCING TETRA (1-VINYLIMIDAZOLE)CABALT DICHLORIDE Russian patent published in 2013 - IPC C07F15/06 A61K31/295

Abstract RU 2473553 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for preparing compendial tetra(1-vinylimidazole)cobalt dichloride (Cobazol). The method involves a reaction of 1-vinylimidazole and cobalt dichloride in the molar relation of 1-vinylimidazole: CoCl₂·6H₂O = 4:1 at room temperature. The process is carried out in an aqueous medium at the concentration of 1-vinylimidazole 20-45%. A cobalt dichloride salt is introduced in the form of a solid crystalline hydrate added to a ligand solution in portions. The reaction is conducted for 3-8 hours. The end product is purified by water stripping in vacuum and then air elimination.

EFFECT: invention enables considerably reducing production costs, providing higher production and ecological safety with preserving higher yield of the compendial preparation Cobazol.

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RU 2 473 553 C1

Authors

Trofimov Boris Aleksandrovich

Gusarova Nina Kuz'Minichna

Shantrokha Aleksandr Viktorovich

Parshina Lidija Nikiforovna

Khil'Ko Marina Jakovlevna

Grishchenko Ljudmila Anatol'Evna

Dates

2013-01-27—Published

2011-11-25—Filed