FIELD: chemistry; biochemistry.
SUBSTANCE: invention pertains to biotechnology. The invention describes an antibody which specifically identifies a membrane or secretory protein selected from several proteins with sequences given in the application materials, or functional fragment thereof. The invention discloses a hybridoma which produces the said antibody and is deposited under inventory No. FERM BP-10376. A medicinal agent used in an autoimmune disease and which contains the described antibody or its functional fragment as an active ingredient is proposed. Described also, is a T cell adhesion inhibiting agent which contains the described antibody or its functional fragment as an active ingredient. The invention discloses a method of screening a substance which inhibits dendritic cell activation, or its salts or solvate involving the following steps: bringing the said antibody or its functional fragment into contact with a dendritic cell in the presence or absence of the substance under test and measuring the activation level of the said dendritic cell.
EFFECT: invention widens the range of agents for treating rheumatoid arthritis.
18 cl, 24 dwg, 12 ex
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| IMMUNITY INDUCING AGENT | 2009 |
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| IMMUNITY INDUCING AGENT | 2013 |
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| IMMUNE-INDUCING AGENT | 2017 |
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| NEW LIGAND OF CYTOKINE RECEPTOR ZCYTOR17 | 2003 |
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| IMMUNITY-INDUCING MEANS | 2012 |
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| NUCLEIC ACID SYNTHETIC MOLECULE (VERSIONS), MAMMAL CELL EXPRESSION VECTOR, MAMMAL HOST CELL AND METHOD OF EXPRESSING ANTIGEN PROTEIN OF HUMAN EPIDERMAL GROWTH FACTOR-2 (HER2/neu) OR SHORTENED FORM THEREOF | 2004 |
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RU2397249C2 |
| IMMUNITY-INDUCING AGENT | 2012 |
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RU2634862C2 |
