FIELD: medicine, pharmaceutics.
SUBSTANCE: declared method refers to preparing 4-methyl-3-[2-(N-propylamino)propionylamino]thiophene-2-carboxylic acid methyl ether hydrochloride (articaine) which is implemented by a reaction of 3-(2-chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene and n-propylamine, transformation of the reaction product into an aqueous solution in the form of hydrochloride which is used to recover 4-methyl-3-[2-(N-propylamino)propionylamino]thiophene-2-carboxylic acid methyl ether hydrochloride by introducing sodium chloride in the amount to provide the concentration of the latter in the reaction mass within the range of 10.0 to 15.0%. The technical effect consists in the fact that there is developed the method for preparing high-yield and high-purity 4-methyl-3-[2-(N-propylamino)propionylamino]thiophene-2-carboxylic acid methyl ether hydrochloride.
EFFECT: prepared product is a local anaesthetic found a wide application in dentistry and surgical practice.
1 cl, 1 ex
