PYRIMIDINE DERIVATIVES USED AS PROTEIN KINASE INHIBITORS Russian patent published in 2013 - IPC C07D487/04 A61K31/551 A61P35/00 A61P19/02 A61P17/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: in formula (VIII):

X represents NR⁷; Y represents O or N-(CH₂)_nR¹⁹; n is equal to 1 or 2; m is equal to 1 or 2; R¹ represents H or C_1-6alkyl; R² independently represents H, C_1-6alkyl or C_5-6cycloalkyl; each of R⁴ and R⁴ independently represents H or C_1-6alkyl; or R⁴ and R⁴ together form spiro-C_3-6cycloalkyl group; R¹⁹ represents H, C_1-6alkyl, C₆aryl or C₃cycloalkyl group; R⁶ represents OR⁸ ; and each of R⁷ and R⁸ independently represents H or C_1-6alkyl. The invention also refers to compounds of formula VI, VII, a pharmaceutical composition containing said compounds, and a method of treating a proliferative disease, such as cancer.

EFFECT: invention refers to new pyrimidine derivatives and their pharmaceutically acceptable salts possessing the properties of a PLK1 kinase inhibitor.

24 cl, 8 tbl, 9 ex