FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (I):
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where E1, E2 independently of each other are –CO– or –SO2–, R* is one of the following residues: –H, –CH3, –C2H5, –C3H7, –CH(CH3)2 or –C4H9, R# is one of the following residues: –NYY’, –OH, –OY, –NH–CH(CH2CH(CH3)2)–CH2COOY’,
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Y is one of the following residues: –CH2R1, –CHR1–CH2R2, –CHR1–CHR2–CH2R3, –CHR1–CHR2–CHR3–CH2R4 or –CHR1–CHR2–CHR3–CHR4–CH2R5; Y’, R17-R20 are selected independently of each other from: –H, –CH3, –C2H5, –C3H7, –CH(CH3)2, –C4H9, –CH2–CH(CH3)2, –CH(CH3)–C2H5, –C(CH3)3, –C5H11, –CH2–C(CH3)3, –CH(C2H5)2 and –C2H4–CH(CH3)2; X is –CR7R8R9, –CH2R7, –CHR7–CH2R8, –O–CH2R7, –O–CR7R8R9,
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Z is: –CH3, –C2H5, –C3H7, –CH(CH3)2, –C4H9, –OCH3, –OC2H5, –OC3H7, –OCH(CH3)2, –OC4H9 or –OCH2–Ph; R1-R10 are independently the following groups –H, –OH, –NO2, -F, –Cl, –Br, –I, –COOH, –COOCH3, –COOC2H5, –COOC3H7, COOCH(CH3)2, –COOC(CH3)3, –NHCOCH3, –NHCOC2H5, –NHCOC3H7, –NHCO–OC(CH3)3, –NH2, –NHCH3, –NHC2H5, –NHC3H7,–NHCH(CH3)2, –NHC(CH3)2, –N(CH3)2, –N(C2H5)2, –N(C3H7)2, –N[CH(CH3)2]2, –N[C(CH3)3]2, –SO2NH2, –NH–CO–NH2, –CF3, cyclo-C3H5, cyclo-C4H7, cyclo-C5H9, cyclo-C6H11, –Ph, –CH2–Ph, –CH3, –C2H5, –C3H7, –CH(CH3)2, –C4H9, –CH2–CH(CH3)2, –CH(CH3)–C2H5, –C(CH3)3, –C5H11, –CH2–C(CH3)3, –CH(C2H5)2, –C6H13,
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EFFECT: residues R11-R16 are independently the following groups: –H, –NH2, –OH, –OCH3, –OC2H5, –OC3H7, –OCF3, –CF3, –F, –Cl, –Br, –I, –CH3, –C2H5, –C3H7 and –CH(CH3)2; their pharmaceutically acceptable salts and their use for the prevention and treatment of diseases associated with tissue transglutaminase.
12 cl, 3 dwg, 79 ex
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Authors
Dates
2018-05-04—Published
2013-07-12—Filed