FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to medicine and describes pharmaceutical composition for injecting, based on homogeneous liquid, containing docetaxel, with controlled pH in the interval from 3 to 5, consisting of: (a) docetaxel or its pharmaceutically acceptable salt, (b) surfactant, selected from group, consisting of polysorbate, polyoxyethylene glycol ester and polyoxyethylene derivatives of castor oil, (c) water-free ethanol in concentration from 100 to 800 mg/ml, and (d) pH regulator, selected from citric acid, fumaric acid, lactic acid, stannic acid, succinic acid, maleic acid, acetic acid, tartaric acid and phosphoric acid.
EFFECT: composition is suitable for efficient introduction of docetaxel as it has improved pharmaceutical stability.
2 cl, 4 ex, 8 tbl
Authors
Dates
2013-04-10—Published
2009-02-26—Filed