METHOD FOR DETECTING ANTIPLATELET DRUG RESISTANCE IN PATIENTS WITH PROGRESSING CEREBRAL ATHEROSCLEROSIS Russian patent published in 2013 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: with underlying antiplatelet therapy, patient's blood is examined for ADP platelet aggregation (ADP -PA) in the concentration of 3 mcmole/l and adrenaline platelet aggregation (ADP -Adr) in the concentration of 2 mcmole/l, von Willebrand factor (vWf) and antithrombin III (AT III) before and after cuff test (CT). The increasing pre-CT ADP -PA values and the considerably increasing post-CT ADP -PA 45.8% and more, the increasing pre-CT ADP -Adr and the considerably increasing post-CT ADP -Adr 46.34% and more, the increasing pre-CT vWf and the considerably increasing post-CT vWf 199.15% and more, and the decreasing pre- and post-CT AT III 98.7% and less show antiplatelet drug resistance with underlying endothelial vascular wall dysfunction.

EFFECT: method provides high-accuracy detection of hypercoagulation syndrome developing despite continuous administration of the antiplatelet drugs in the patients with progressing atherosclerosis of the major artery of the head.

1 dwg, 2 ex