CONTROLLED RELEASE COMPOSITION FOR PREPARING PROLONGED RELEASE PREPARATION CONTAINING UDENAFIL Russian patent published in 2013 - IPC A61K47/48 A61K9/22 A61K31/519 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a controlled release compositions for preparing a prolonged release Udenafil containing preparation comprising (A) Udenafil or a pharmaceutically acceptable salt thereof, (B) a solubility modulator, (C) an adsorbent, and (D) a hydrophilic polymer. The controlled release composition for preparing the prolonged release Udenafil containing preparation releases a drug substance continuously, regardless of the gastrointestinal pH value, and thereby freely controls the drug substance release within 3-24 hours and reduces the variability of the individual effects of the drugs. In addition, this composition may be used in preparing the prolonged release of the drug which has an optimum condition for the manifested effect of the drug in treating the diseases including pulmonary arterial hypertension, portal hypertension, benign prostate hyperplasia, etc., which can be treated by Udenafil and require long-term administration of the drugs.

EFFECT: composition can control the drug release in accordance with the absorption length when the drug is administered into a living body, and thereby the use thereby may be of prime importance for the prevention and treatment of erectile dysfunction.

9 cl, 3 dwg, 7 tbl, 22 ex