3,3-DIFLUOROPIPERIDINE CARBAMATE HETEROCYCLIC COMPOUNDS AS NR2B NMDA RECEPTOR ANTAGONISTS Russian patent published in 2020 - IPC A61K31/4545 A61K31/497 A61K31/4985 A61K31/506 A61K31/519 A61P25/00 A61P25/04 A61P25/06 A61P25/08 A61P25/14 A61P25/16 A61P25/24 A61P25/28 A61P43/00 C07D401/12 C07D471/04 C07D487/04 

Abstract RU 2735277 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a chemical compound of formula (II), as well as to pharmaceutical compositions containing a chemical compound of formula (II), and to methods of treating various diseases and disorders, associated with NR2B antagonism, e.g. diseases and CNS disorders, such as depression, by administering a chemical compound of formula (II).

EFFECT: in this invention 3,3-difluoropiperidine carbamate heterocyclic compounds are proposed as NR2B NMDA receptor antagonists.

7 cl, 51 ex, 10 tbl, 11 dwg

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RU 2 735 277 C2

Authors

Shapiro, Gideon

Dates

2020-10-29Published

2016-05-31Filed