FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, and concerns an agent for prevention and treatment of cardiovascular diseases. The peptide 3-mercaptopropionyl-Phe-Ile-lle-Arg-Lys-Pro-Asp-Lys-NH2 is synthetised which has greater availability and lower price than known analogues; it possesses the antiplatelet, anti-inflammatory and cytoprotective properties.
EFFECT: invention provides reduced spontaneous thrombocyte aggregation, inflammation inhibition by reducing histamine secretion, cell protection against neurotoxic actions of thrombin.
1 cl, 4 ex
| Title |
Year |
Author |
Number |
| METHOD FOR ASSESSING COMPLEX PROTECTION OF CELLS UNDER NEURO-INFLAMMATORY ON IN VITRO MODELS UNDER EXPOSURE TO PAR1 AGONIST |
2022 |
- Babkina Irina Igorevna
- Gorbacheva Lyubov Rufelevna
- Kiseleva Ekaterina Vladimirovna
- Sidorova Mariya Vladimirovna
|
RU2796524C1 |
| RECOMBINANT POLYPEPTIDE, METHOD OF INHIBITION OF PLATELET AGGREGATION, RECOMBINANT PLASMID DNA (VARIANTS), RECOMBINANT STRAIN OF ESCHERICHIA COLI (VARIANTS), METHOD OF POLYPEPTIDE PREPARING |
1991 |
- Leonard Garfinkel'[Us]
- Tamar Rikhter[Il]
|
RU2109816C1 |
| EXTRACELLULAR DOMAIN OF ALPHA SUBUNIT OF IgE Fc RECEPTOR, A PHARMACEUTICAL COMPOSITION CONTAINING IT AND A METHOD FOR ITS PRODUCTION |
2019 |
- Sung, Young Chul
- Yang, Zungyoon
|
RU2796162C2 |
| NOVEL HUMANISED ANTIBODIES TO FACTOR XI WITH ANTITHROMBOTIC AND ANTI-INFLAMMATORY ACTION AND USE THEREOF |
2020 |
- Gruber Andras
- Taker Erik Aj
- Lorents Kristina U.
|
RU2817219C2 |
| VARIANTS WITH Fc-FRAGMENT, HAVING HIGH AFFINITY TO FcRn AND HIGH AFFINITY TO AT LEAST ONE RECEPTOR OF Fc-FRAGMENT |
2018 |
- Meade, Garri
- Monne, Selin
- Mondon, Filipp
|
RU2820162C2 |
| FUSED MOLECULE CAPABLE OF INDUCING NON-INFLAMMATORY PHAGOCYTOSIS |
2022 |
- Kim, Chan Hyuk
- Chung, Won Suk
- Jung, Hyun Cheol
- Lee, Se Young
|
RU2823919C1 |
| METHOD FOR NEUROPROTECTION IN EXPERIMENT |
2015 |
- Sidorova Mariya Vladimirovna
- Kiseleva Ekaterina Vladimirovna
- Gorbacheva Lyubov Rufelevna
- Strukova Svetlana Mikhajlovna
- Mojsenovich Mikhail Mikhajlovich
- Agapov Igor Ivanovich
- Goncharenko Anna Vladimirovna
- Arkhipova Anastasiya Yurevna
- Kotlyarova Mariya Sergeevna
- Ramonova Alla Alikovna
|
RU2616509C1 |
| COMPOSITION CONTAINING PROBIOTICS AND POLYPEPTIDE HAVING BINDING AFFINITY RELATIVELY TO IgE AND ITS USE |
2019 |
- Jang, Myoung Ho
- Sung, Young Chul
- Yang, Zungyoon
|
RU2786578C2 |
| METHODS OF TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION |
2012 |
- Demopulos, Gregory, A.
- Dudler, Tom
- Schwaeble, Hans-Wilhelm
|
RU2743409C2 |
| METHODS AND COMPOSITIONS FOR TREATING GASTROINTESTINAL DISORDERS |
2004 |
- Karri Mark Dzh
- Makhadzhan-Miklos Shalin
- Norman Tea
- Miln Todd Dzh
|
RU2543350C2 |
