OXYNTOMODULIN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, METHOD OF TREATING AND PREVENTING OBESITY AND COMORBIDITIES (VERSIONS) AND MEDICINE (VERSIONS) Russian patent published in 2013 - IPC C07K14/605 A61K38/26 A61P3/04 

Abstract RU 2485135 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: compounds of the present invention are novel peptide analogues of oxyntomodulin (oxm) wherein one or more amino acid residue of the sequence oxm are replaced. The replacement of amino acid residues 15-24 of the peptide oxm either by amino acid residues 968-977 of the α-latroxin peptide (and versions thereof), or by amino acid residues 15-24 of extendin-4 (and versions thereof), or combining the amino acid residues of these sources, and/or the replacement of amino acid residues 27-33 of the peptide oxm by amino acid residues 27-33 of extendin-4, and/or adding the amino acid residues to an C-terminal of the peptide, enables producing a number of the analogues oxm presenting oxm-like activity to reduce food consumption, and according to some other aspects, more evident ability to reduce food consumption.

EFFECT: reduced food consumption.

32 cl, 779 dwg, 106 ex

Similar patents RU2485135C2

Title Year Author Number
PEPTIDE, PHARMACEUTICAL COMPOSITION (VERSIONS) AND MEDICATION 2007
  • Blum Stiven Robert
RU2492183C2
PHARMACEUTICAL COMPOSITIONS CONTAINING PEPTIDE VERSIONS, AND METHODS OF USING THEM 2015
  • Lindhout, Darrin, Anthony
  • Olson, Charles, V.
RU2729161C2
VERSIONS OF FACTOR N-BINDING PROTEIN AND METHODS OF USE THEREOF 2015
  • Birnink Piter T.
RU2714248C2
OPTIONS FOR H-BINDING PROTEIN FACTOR AND METHODS OF THEIR USE 2015
  • Beernink, Peter T.
RU2811942C2
FUSED MOLECULES DERIVED FROM CHOLIX-TOXIN FOR ORAL DELIVERY OF BIOLOGICALLY ACTIVE LOADS 2015
  • Mrsny Randall J.
  • Mahmood Tahir
RU2723178C2
STRUCTURES HAVING SIRP-ALPHA DOMAIN OR ITS VERSION 2016
  • Ponz Khaume
  • Deming Laura
  • Gudman Kori
  • Sim Bang Dzhanet
  • Kauder Stiven Elliot
  • Van Khun
  • Ko Trejsi Chia-Chien
RU2740672C2
EMBODIMENTS OF IGG-Fc FOR USE IN VETERINARY SCIENCE 2018
  • Chzhan, Khantszyun
  • Ngujen, Lam
  • Li, Yunchzhun
  • Tsyan, Fon
  • Li, Shir Tszyann
RU2814952C2
INTERLEUKIN-18 OPTIONS AND METHODS FOR THEIR USE 2018
  • Ring, Aaron
  • Zhou, Ting
  • Fischer, Suzanne
RU2797536C2
IL-12 COMPOSITIONS AIMED AT EDB 2019
  • Villa, Alessandra
  • Matasci, Mattia
  • Ongaro, Tiziano
RU2758143C1
NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS FOR USING THEM 2017
  • Anderson Annaliesa Sybil
  • Hoiseth Susan Kay
  • Jansen Kathrin Ute
  • Moran Justin Keith
  • Ruppen Mark E.
RU2739504C2

RU 2 485 135 C2

Authors

Blum Stiven Robert

Gatej Mokhammad Ali

Dates

2013-06-20Published

2006-06-13Filed