FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, namely to a polypeptide which activates the epithelial ion channels. The presented invention can be used for producing a drug preparation for diseases related to pulmonary function, such as oedemas. The presented polypeptide is an amino acid sequence of a region from valine Val(91) to glycine Gly(121) of the mature human tumour necrosis factor, or a functionally active fragment thereof, provided the polypeptide or fragment thereof comprises at least an amino acid sequence of a region from lysine Lys(98) to glutamic acid Glu(116), wherein cysteine Cys(101) is substituted by glycine, and an amide bond is formed between an amino group of a side chain of lysine Lys(98) and a carboxyl group of a side chain of glutamic acid Glu(116).
EFFECT: presented invention enables activating the epithelial ion channels and improves the pulmonary function.
5 cl, 6 dwg, 3 tbl, 7 ex
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