FIELD: biotechnologies.
SUBSTANCE: extracted polynucleotides and polypeptides are proposed to bind a human EGFR within an antibody, a vector and a master cell for expression of an antibody, the method to produce an anti-EGFR of antibody or an antibody fragment, an anti-ERFR antibody and an antibody fragment. A composition is considered, which contains an anti-EGFR antibody or its fragment, its application, and also application of the antibody and its fragment for treatment of disorders associated with EGFR. Besides, the method is described to detect presence of EGFR in the sample with the help of the antibody according to the invention. This invention relates to humanised versions of the rat antibody ICR62 and thus may find further application in therapy of EGFR-mediated diseases.
EFFECT: improved efficiency of compound application.
85 cl, 5 ex, 29 dwg, 38 tbl
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