METHOD OF THERAPEUTIC DISCRETE PLASMAPHERESIS WITH EXTRACORPOREAL ERYTHROXYTE AND LEUKOCYTE MODIFICATION WITH INTERFERON INDUCERS, ANTIOXIDANTS AND CELL PROTECTORS Russian patent published in 2013 - IPC A61M1/36 

FIELD: medicine.

SUBSTANCE: invention refers to immunology, transfusion medicine and intensive therapy, and may be used to treat endotoxemias of various aethiologies. That is ensured by blood sampling, centrifuging to plasma and erythrocyte-leukocyte mass. The leukocyte suspension is added with interferon inducers, hepatoprotectors and antioxidants in sub-therapeutic doses. The leukocyte suspension is incubated at t - 37°C for 120 min, and then introduced into the patient's venous bed. The erythrocyte mass is added with cerebroprotectors, hepatoprotectors and antioxidants in sub-therapeutic doses. The erythrocyte mass is incubated at t - 37°C for 45 min, and then introduced into the patient's venous bed. With no contraindications, the second session of each cycle involves the exposure to ultrasound (ultraviolet irradiation 150 J) preceding the incubation of the leukocyte suspension with the added therapeutic preparations. The length of treatment makes three 5-session cycles in average every 2 days as recommended. The length of each session is min. 3.5 hours and max. 4.5 hours. The 1st and 2^nd cycles are separated by 2 weeks, while the 2^nd and 3^rd ones - by 4 weeks. The total therapeutic course makes 2-3 months.

EFFECT: method provides the fast recovery of quality of life in the patients suffering endotoxemias due to the optimal selection of the centrifugation parameters, incubation regimens and optimal ultrasound power.

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