PHARMACEUTICALLY EFFECTIVE COMPOUNDS SELECTIVELY INHIBITING MYOSIN 2 ISOFORMS Russian patent published in 2024 - IPC C07D471/04 C07D471/14 C07D487/14 C07D491/14 C07D495/14 A61K31/4375 A61K31/5377 A61P7/02 A61P25/18 A61P35/00 A61P35/02 A61P35/04 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry and includes a compound of formula (I) or (II), pharmaceutically acceptable salts and enantiomers thereof, individual compounds specified in the claim, as well as use of the compounds. In formula (I), R¹ is an H atom or a group of formula in which R⁶ and R¹⁰ are an H atom; R⁷, R⁸ and R⁹ are each independently H, saturated 6-member heterocyclic group containing two heteroatoms selected from N and O, C_1-12 straight or branched alkyl, C_1-12 dialkylamino , C_1-12 alkoxy, which can be substituted with one to three halogen atoms, or acetyl; R², R³ , R⁴ and R⁵ represent an H atom; each of one or more Q¹, Q², Q³ and Q⁴ is independently selected from a group consisting of an N atom, and others are CH. In formula (II), R¹ is an H atom or a group of formula in which R⁶ and R¹⁰ are an H atom; R⁷, R⁸ and R⁹ are each independently H, saturated 6-member heterocyclic group containing two heteroatoms, selected from N and O, NH₂, CN, C_1-12 straight or branched alkyl, C_1-12 alkoxy, which can be substituted with one to three halogen atoms, C_1-12 hydroxyalkyl , C_1-12 dialkylamino , C_1-12 alkylcyano or acetyl; R², R³, R⁴ and R⁵ represent an H atom; each of Q⁵, Q⁶ and Q⁷ is independently S or N.

EFFECT: disclosed are compounds of formulas (I) or (II), having inhibitory activity on sarcomeric myosin 2 isoforms.

25 cl, 1 dwg, 11 tbl, 11 ex