METHOD OF PRODUCING CASPOFUNGIN AND INTERMEDIATE COMPOUNDS THEREOF Russian patent published in 2013 - IPC C07K7/56 C07K1/113 A61K38/12 A61K31/10

Abstract RU 2489442 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel intermediate compounds of the given formula or acid-addition salts or solvates thereof, where R₁ is -(CO)NH₂, -CH₂NH₂ or -CN; R₂=R₃=H or R₂ and R₃ together form a cyclic boronate or a boric acid ester; X is an auxiliary group consisting of i) a five- or six-member heterocyclic aromatic ring containing at least one N atom, which is part of an imino group, where said N atom forms a bonding site for a cyclohexapetide ring and ii) tetrazolyl, for which the nitrogen forms a bonding site for a cyclohexapeptide ring. The present invention also relates to a method of producing caspofungin using said intermediate compounds.

EFFECT: improved method.

11 cl, 9 ex

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RU 2 489 442 C2

Authors

Kheggelund Audun

Kvernenes Ole Khejne

Bjornstad Vidar

Dates

2013-08-10—Published

2009-06-11—Filed