METHOD FOR PREPARING 3-(o-, m-, n-NITROPHENYL)-TETRAHYDRO-2H-1,5,3-DIOXAZEPINES Russian patent published in 2013 - IPC C07D273/01 

Abstract RU 2490262 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, particularly to a method for preparing 3-(o,m,n-nitrophenyl)-tetrahydro-2H-1,5,3 -dioxazepines of general formula (I): which consists in the fact that a mixture of formaldehyde and 1,2-enandithiole prepared at 20°C for 30 min is added with the catalyst Sm(NO3)3·6H2O, o-(or m-, or n)nitroaniline at molar ratio of o-(or m-, or n-)nitroaniline : formaldehyde : 1,2-ethandiole : Sm(NO3)3·6H2O = 10 : 20 : 10 : 0.5, to be mixed at room (~20°C) temperature for 50-40 min in chloroform.

EFFECT: what is developed is the method for preparing new individual 3-(o-,m-, n-nitrophenyl)-tetrahydro-2H-1,5,3-dioxazepines that can find application as antibacterial, antifungal and antiviral agents and in fine organic synthesis.

1 cl, 1 tbl, 1 ex

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RU 2 490 262 C2

Authors

Dzhemilev Usein Memetovich

Murzakova Natalija Nail'Evna

Prokof'Ev Kirill Igorevich

Akhmetova Vnira Rakhimovna

Ibragimov Askhat Gabdrakhmanovich

Korzhova Ljubov' Fedorovna

Dates

2013-08-20Published

2011-06-09Filed