FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to organic chemistry, particularly to a method for preparing 3-(m,n-methylphenyl)-tetrahydro-2H-1,5,3 -dioxazepines of general formula (1):
which consists in the fact that a mixture of formaldehyde and 1,2-ethandiole prepared at 20°C for 30 min is added with the catalyst Sm(NO3)3·6H2O, m-, or n-methylaniline at molar ratio of m-, or n-methylaniline : formaldehyde : 1,2-ethandiole : Sm(NO3)3·6H2O = 10 : 20 : 10 : 0.5, to be mixed at room (~20°C) temperature for 50-40 min in chloroform.
EFFECT: what is developed is the method for preparing new individual 3-(m-, n-methylphenyl)-tetrahydro-2H-1,5,3-dioxazepines that can find application as antibacterial, antifungal and antiviral agents and in fine organic synthesis.
1 cl, 1 tbl, 1 ex
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