METHOD FOR PREPARING CONJUGATE OF (6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-YL)ACETALDEHYDE AND 20-HYDROXYECDYSONE AND USING IT AS ANTIOXIDANT AGENT INHIBITING LIPID PEROXIDATION PROCESS Russian patent published in 2013 - IPC C07D407/06 C07J71/00 A61K31/58 A61P1/16 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry and chemistry of natural products, more specifically to a method for preparing a new compound, a 20-hydroxyecdysone derivate conjugated with a short-chain vitamin E analogue, promising for medicine and pharmacology, namely to a method for preparing a 20-hydroxyecdysone conjugate by a reaction thereof with (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetaldehyde in ethyl acetate at room temperature in the absence of an acid catalyst (TsOH or phosphonomolybdic acid) for 24 h, debenzylation of the prepared intermediate conjugate in the ethanol solution in the presence of the catalyst Pd-C. The invention also refers to using such compound as an antioxidant agent inhibiting the lipid peroxidation process.

EFFECT: prepared hybride compounds appears to be promising in medicine and pharmacology as the new geroprotective antioxidants.

3 cl, 3 tbl, 3 ex