FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing a novel compound, a derivative of diacetonide 20-hydroxyecdysone with a novel regrouped 18-methyl group. Described is a method of producing a C27-steroid with a regrouped methyl group via hydrogenation over a palladium catalyst (10% Pd/C) in a solution of an alcohol (preferably methanol) in the presence of an alcoholate of an alkali metal (preferably sodium methylate), diacetonide 9α, 14α-epoxy-14-desoxy-20-hydroxyecdysone or diacetonide 14α-hydroperoxy-20-hydroxyecdysone, or Δ8(14) - 14-desoxy-20-hydroxyecdysone, followed by treatment of the reaction mixture with ammonium chloride solution and extraction of the desired 2,3:20,22-diacetonide 9α, 13α-epoxy-14β-methyl-13-demethyl-14-desoxy-7,8-dihydro-20-hydroxyecdysone using known techniques with output of 60-65%.
EFFECT: obtaining a novel useful compound.
1 cl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCING 2,3-DEOXY-ΔECDYSTEROIDS | 2020 |
|
RU2760001C1 |
| METHOD OF PRODUCING 2,3-MONOACETONIDE 20-HYDROXYECDYSONE | 2007 |
|
RU2351604C1 |
| METHOD FOR PREPARING CONJUGATE OF (6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-YL)ACETALDEHYDE AND 20-HYDROXYECDYSONE AND USING IT AS ANTIOXIDANT AGENT INHIBITING LIPID PEROXIDATION PROCESS | 2010 |
|
RU2490267C2 |
| METHOD OF PRODUCING 2-DEHYDRO-3-EPI-20-HYDROXYECDYSONE, MINOR ECDYSTEROIDS OF Froelichia floridana SEEDS | 2008 |
|
RU2397177C2 |
| METHOD OF PRODUCING 7,8-DIHYDRO-ANALOGUES OF ECDYSTEROIDS | 2010 |
|
RU2434877C1 |
| METHOD FOR PREPARING α-ECDYSONE | 2003 |
|
RU2246966C1 |
| METHOD TO OBTAIN SHIDASTERONE | 2001 |
|
RU2183641C1 |
| AGENT "EKDISTERON-80" POSSESSING CARDIOPROTECTIVE, ADAPTOGENIC, ANTI-HYPOXIC, GASTROPROTECTIVE, THERMOPROTECTIVE, ANABOLIC AND ACTOPROTECTIVE ACTIVITY AND METHOD FOR ITS PRODUCTION | 2006 |
|
RU2321420C1 |
| 14-SUBSTITUTED MARCFORTINES | 1994 |
|
RU2131877C1 |
| ANTIPARASITIC MARCFORTINES AND PARAHERCVAMIDES | 1996 |
|
RU2162090C2 |
