METHOD OF TREATING OR PREVENTING AUTOIMMUNE DISEASES BY 2,4-PYRIMIDINEDIAMINE COMPOUNDS Russian patent published in 2013 - IPC A61K31/506 C07D401/12 C07D403/12 C07D405/12 C07D407/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of structural formula (1a) possessing the properties of Syk-kinase inhibitors, pharmaceutically acceptable salts thereof, as well as to a based pharmaceutical composition. In general formula (1a), R⁴ represents or , R² is specified in a group consisting of phenyl which can be substituted by one or more identical or different groups R⁸, (C1-C6) alkyl, and pyridyl can be substituted by one or more identical or different groups R⁸. R⁵ represents fluorine; each R⁶ represents hydrogen. The other radical values are specified in the patent claim.

EFFECT: compounds may be used for treating or preventing the autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematous, as well as multiple sclerosis.

12 cl, 11 ex, 16 dwg, 11 tbl