2,4-PYRIMIDINE DIAMINE COMPOUNDS AND USE THEREOF Russian patent published in 2013 - IPC C07D239/28 C07D239/48 C07D401/12 C07D401/14 C07D403/14 C07D403/12 C07D405/12 C07D405/14 C07D409/12 C07D413/12 C07D413/14 A61K31/519 A61K31/505 A61P37/00 A61P37/08 A61P11/06 

FIELD: chemistry.

SUBSTANCE: invention relates to novel of 2,4-pyrimidine diamine compounds of formula I, which inhibit degranulation of immune cells and can be used in treating cell reactions mediated by FcεRI or FcγRl receptors. In formula (I) each R² and R⁴ is independently phenyl substituted with one or more R⁸ groups or a heteroaryl selected from a group consisting of , where the heteroaryl is optionally substituted with one or more R⁸ groups and at least one of R² and R⁴ is a heteroaryl; R⁵ is selected from a group consisting of (C1-C6)alkyl, optionally substituted with one or more identical or different R⁸ groups, -OR^d, -SR^d, fluorine, (C1-C3)halogenalkyloxy, (C1-C3)perhalogenalkyloxy, -NR^cR^c, (C1-C3)halogenalkyl, -CN, -NO₂, -C(O)R^d, -C(O)OR^d, -C(O)NR^cR^c, -C(NH)NR^cR^c, -OC(O)R^d, -OC(O)OR^d, -OC(O)NR^cR^c; -OC(NH)NR^cR^c, - [NHC(O)]_nOR^d, R³⁵ is hydrogen or R⁸; each Y is independently selected from a group consisting of O, S and NH; each Y¹ is independently selected from a group consisting of O, S and NH; each Y² is independently selected from a group consisting of CH, CH₂, S, N, NH and NR³⁷. Other values of radicals are given in the claim.

EFFECT: improved efficiency.

19 cl, 6 tbl.