DIAGNOSTICUM FOR IDENTIFYING DONOR-SPECIFIC MAJOR HISTOCOMPATIBILITY COMPLEX ANTIBODIES AND METHOD FOR PREPARING IT Russian patent published in 2013 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: diagnosticum comprises human lymphocytes to identify donor-specific major histocompatibility complex antigen antibodies during the post-transplant period, characterised by the fact that the diagnosticum comprises lymphocytes obtained from the multiorgan donor's spleen; a method for preparing a diagnosticum, predicting a rejection reactions following the transplantation from multiorgan donors, including a reaction to identify the donor-specific major histocompatibility complex antigen antibodies, characterised by the fact that the above diagnosticum is used. The diagnosticum contains T lymphocytes bearing the class I major histocompatibility complex antigens, and B lymphocytes bearing the class II major histocompatibility complex antigens in ratio suitable to provide an adequate antigen-antibody reaction in studying the donor-specific class I and II HLA antibodies in recipient's serum for a long transplantation period for humoral rejection diagnosis and evaluation of the immunosuppression therapy effectiveness.

EFFECT: preparing the high-quality diagnosticum.

4 cl, 2 ex, 2 tbl