NEW PHOSPHODIESTERASE INHIBITORS Russian patent published in 2013 - IPC C07D491/113 C07D493/20 C07D495/10 A61K31/36 A61P29/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a compound of general formula (I): wherein m and n independently represent 0 or 1; G and E represent oxygen, R₁ and R₂ together with a carbon atom whereto attached form a heterocycle including one or two heteroatoms specified in oxygen, sulphur, -S(O)-, -S(O)₂-, -N=, -N(R₅)-; one or more carbon atoms in the above heterocycle are optionally substituted by one or more identical or different substitutes specified among the substitutes R₄; R₃ represents alkoxy or halogenoxy; R₄ represents hydrogen, alkyl or halogen; R₅ represents hydrogen, alkyl carbonyl, alkoxy carbonyl or alkyl sulphonyl; X represents a bond, -CH₂- or -NH-; A represents phenyl, pyridyl, pyrazynyl or quinolyl optionally substituted by one or more identical or different substitutes specified among the substitutes R₄; or pharmaceutically acceptable salts, hydrates, N-oxides or salvates thereof.

EFFECT: invention also refers to the pharmaceutical composition of the above compounds as the phosphodiesterase PDE4 inhibitor for treating, eg skin diseases.

19 cl, 2 tbl, 32 ex