FIELD: biotechnologies.
SUBSTANCE: single-domain antibody (nanoantibody) is proposed, which specifically binds a carcino-embrional antigen (CEA) of a human being and characterised by a full amino acid sequence. Also the method is considered to detect a CEA protein in biological fluids and tissues of a human being with usage of a nanoantibody according to the invention.
EFFECT: invention may find further application in diagnostics and therapy of cancer.
3 cl, 4 dwg, 4 ex
| Title |
Year |
Author |
Number |
| NANOANTIBODY SPECIFICALLY BINDING MUC1 PROTEIN, METHOD OF MUC1 PROTEIN DETECTION BY NANOANTIBODIES |
2012 |
- Tillib Sergej Vladimirovich
|
RU2493165C1 |
| SINGLE-DOMAIN MINI-ANTIBODY aHER2/aSKBR3-1, SPECIFICALLY BINDING EPIDERMAL GROWTH FACTOR RECEPTOR HER2/ERBB2/neu AND CAPABLE TO PENETRATE THROUGH THIS INTERACTION INTO TARGET CELLS (INTERNALISED), METHOD OF PRODUCTION OF THIS ANTIBODY AND METHOD OF DETECTION OF PROTEIN HER2/ERBB2/neu AND CELLS EXPRESSING THIS PROTEIN IN INCREASED AMOUNT, USING MINI-ANTIBODY aHER2/aSKBR3-1 |
2012 |
- Tillib Sergej Vladimirovich
- Ivanova Tat'Jana Il'Inichna
- Vasil'Ev Lev Anatol'Evich
- Deev Sergej Mikhajlovich
- Zdobnova Tat'Jana Aleksandrovna
- Zagajnova Elena Vadimovna
|
RU2522929C2 |
| SINGLE-DOMAIN ANTIBODY aMts1 SPECIFICALLY BINDING PROTEIN S100A4/Mts1, METHOD FOR PREPARING AND USING FOR DETECTION OF THIS PROTEIN |
2012 |
- Tillib Sergej Vladimirovich
|
RU2484096C1 |
| RECOMBINANT SINGLE-DOMAIN ANTIBODIES SPECIFICALLY BINDING F4/80 PROTEIN, METHOD FOR PRODUCTION THEREOF AND USE FOR DETECTION OF SAID PROTEIN |
2015 |
- Tillib Sergej Vladimirovich
- Nedospasov Sergej Arturovich
- Efimov Grigorij Aleksandrovich
- Rozov Fedor Nikolaevich
- Goryajnova Oksana Sergeevna
- Ivanova Tatyana Ilinichna
- Rutovskaya Marina Vladimirovna
|
RU2599423C1 |
| NANOANTIBODIES aMh1, aMh2 BINDING ANTIGEN OF MYCOPLASMA HOMINTS, METHOD OF PRODUCING THEM, METHOD OF TREATING MYCOPLASMA HOMINIS INFECTION |
2011 |
- Logunov Denis Jur'Evich
- Tillib Sergej Vladimirovich
|
RU2484095C1 |
| NANOANTIBODIES BINDING CHLAMYDIA TRACHOMATIS ANTIGEN, METHOD OF INHIBITING INFECTION CAUSED BY CHLAMYDIA TRACHOMATIS |
2012 |
- Zigangirova Nailja Akhatovna
- Tillib Sergej Vladimirovich
|
RU2487724C1 |
| RECOMBINANT SINGLE-DOMAIN ANTIBODIES SPECIFICALLY BINDING HUMAN INTERLEUKIN-6, METHOD FOR THEIR PREPARING AND USING FOR DETECTION OF THIS PROTEIN |
2015 |
- Tillib Sergej Vladimirovich
- Nedospasov Sergej Arturovich
- Efimov Grigorij Aleksandrovich
- Drutskaja Marina Sergeevna
- Kruglov Andrej Alekseevich
- Gorjajnova Oksana Sergeevna
- Ivanova Tatjana Ilinichna
|
RU2603269C1 |
| POLYPEPTIDE MODULE FOR BINDING CONSERVATIVE EPITOPE OF RECEPTOR-BINDING DOMAIN OF SPIKE PROTEIN OF SARS-CoV-2 CORONAVIRUS |
2022 |
- Tillib Sergej Vladimirovich
- Vorobev Pavel Olegovich
|
RU2809183C1 |
| TRIMERISED SINGLE-DOMAIN ANTIBODY THAT SPECIFICALLY BINDS WITH GLYCOPROTEIN G OF RABIES VIRUS, NEUTRALISING RABIES VIRUS |
2013 |
- Tillib Sergej Vladimirovich
- Ivanova Tat'Jana Il'Inichna
- Vasil'Ev Lev Anatol'Evich
- Metlin Artem Evgen'Evich
- Shmarov Maksim Mikhajlovich
- Logunov Denis Jur'Evich
- Tutykhina Irina Leonidovna
- Alekseeva Svetlana Viktorovna
- Naroditskij Boris Savel'Evich
- Gintsburg Aleksandr Leonidovich
|
RU2533802C1 |
| VEGF BINDING V93 NANOANTIBODY AND METHOD OF OBTAINING SAID ANTIBODY, V93-CODING NUCLEOTIDE SEQUENCE AND VECTOR CONTAINING SAID SEQUENCE, ENDOTHELIAL CELL PROLIFERATION INHIBITION METHOD |
2008 |
- Tillib Sergej Vladimirovich
- Vjatchanin Anton Sergeevich
- Ivanova Tat'Jana Il'Inichna
- Korobko Igor' Viktorovich
- Larin Sergej Sergeevich
- Kibardin Aleksej Vladimirovich
- Zakharova Elena Sergeevna
- Korobko Elena Vladimirovna
- Kalinichenko Svetlana Viktorovna
- Vikhreva Polina Nikitichna
- Gnuchev Nikolaj Vasil'Evich
- Georgiev Georgij Pavlovich
|
RU2395522C1 |
