FIELD: biotechnology.
SUBSTANCE: single-domain mini-antibody is proposed, specifically binding the protein-receptor of epidermal growth factor of human HER2/ERBB2/neu obtained by immunisation of two-humped camel (Camelus bactrianus) by the preparation of tumour cells SKBR3, and characterised by the amino acid sequence. Also the method of detecting protein HER2/ERBB2/neu and its expressing cells is considered. The antibody according to the present invention is able to penetrate in the target cell on which surface HER2/ERBB2/neu is exposed, and may find further application in diagnostics and therapy of diseases associated with overexpression of HER2/ERBB2/neu.
EFFECT: improving efficiency of use of the compound.
2 cl, 6 dwg, 5 ex
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