FIELD: biotechnology.
SUBSTANCE: trimerised single-domain antibody is created, that binds specifically with the surface (capsid) protein - glycoprotein G of rabies virus, having an amino acid sequence of SEQ ID NO: 2, which amino acid sequence is encoded by the nucleotide sequence of SEQ ID NO: 1, and at that neutralising the infectious activity of rabies virus.
EFFECT: improvement of properties of the compound.
3 cl, 4 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2661028C2 |
| GENETIC CONSTRUCT BASED ON AN OPTIMIZED GENE OF RABIES VIRUS CONSENSUS GLYCOPROTEIN FOR PREVENTING RABIES | 2018 |
|
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| NUCLEOTIDE SEQUENCE OPTIMIZED FOR EXPRESSION IN BACTERIA OF CONSENSUS GLYCOPROTEIN OF RABIES VIRUS | 2018 |
|
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| NEUTRALIZING MONOCLONAL ANTIBODY BINDING TO RABIES VIRUS GLYCOPROTEIN G, DNA FRAGMENTS CODING SAID ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2017 |
|
RU2718835C2 |
| PREPARATION BASED ON NEUTRALIZING MONOCLONAL ANTIBODIES BINDING WITH GLYCOPROTEIN OF RABIES VIRUS | 2018 |
|
RU2711553C1 |
| NANOANTIBODY SPECIFICALLY BINDING CEA PROTEIN, METHOD OF ITS USAGE FOR DETECTION OF THIS PROTEIN | 2012 |
|
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| ANTIVIRAL SIMILAR MINI-ANTIBODY, NUCLEOTIDE SEQUENCE, EXPRESSING RECOMBINANT VIRAL VECTOR, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREVENTION OR THERAPY OF INFLUENZA TYPE A | 2013 |
|
RU2536956C1 |
| SINGLE-DOMAIN MINI-ANTIBODY aHER2/aSKBR3-1, SPECIFICALLY BINDING EPIDERMAL GROWTH FACTOR RECEPTOR HER2/ERBB2/neu AND CAPABLE TO PENETRATE THROUGH THIS INTERACTION INTO TARGET CELLS (INTERNALISED), METHOD OF PRODUCTION OF THIS ANTIBODY AND METHOD OF DETECTION OF PROTEIN HER2/ERBB2/neu AND CELLS EXPRESSING THIS PROTEIN IN INCREASED AMOUNT, USING MINI-ANTIBODY aHER2/aSKBR3-1 | 2012 |
|
RU2522929C2 |
| HUMANISED ANTIGEN-BINDING FRAGMENTS (Fab) AGAINST RABIES VIRUS, ISOLATED DNA FRAGMENT, CODING Fab AGAINST RABIES VIRUS, YEAST CELL, TRANSFORMED BY DNA FRAGMENT, AND METHOD OF OBTAINING Fab AGAINST RABIES VIRUS WITH APPLICATION OF YEASTS | 2010 |
|
RU2440412C2 |
| SINGLE-DOMAIN ANTIBODY aMts1 SPECIFICALLY BINDING PROTEIN S100A4/Mts1, METHOD FOR PREPARING AND USING FOR DETECTION OF THIS PROTEIN | 2012 |
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RU2484096C1 |
