METHOD FOR PREPARING BIOLOGICAL HYDROXYAPATITE Russian patent published in 2013 - IPC A61K35/32 A61L27/12 B82B1/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers medicine, namely to preparing biological hydroxyapatite. What is described is a method for preparing biological hydroxyapatite involving pre-cleaning of bones, grinding, dissolving of bone tissue in hydrochloric acid, hydroxyapatite precipitation using a precipitant, filtration, heat treatment and deposit grinding; bones are ground to a particle size of 2.5-5 cm; bone tissue is dissolved hydrochloric acid of the concentration of 0.5-2M; that is followed by separating a liquid fraction of the suspension by filtration with the filtered solution added with chitosan of the concentration of 1.5-2 wt % at constant mixing until completely dissolved. The hydroxyapatite precipitant is 3-5M sodium hydroxide or potassium hydroxide added at constant mixing to ensure pH 7.0-7.5 of the reaction mixture; the filtered precipitation is heat treated by calcination at temperature 830°C for at least 40 minutes

EFFECT: fine hydroxyapatite powder of the particle size of 5 nm having the composition of microelements being as close as possible to that of human bone tissue.

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