METHOD OF PRODUCING NANO-SIZED CALCIUM-DEFICIENT CARBONATE-CONTAINING HYDROXYAPATITE Russian patent published in 2016 - IPC C01F11/00 C01B25/32 C01F11/18 B82B3/00 B82Y30/00 A61L27/12 A61K6/33 

FIELD: medicine.

SUBSTANCE: invention can be used in production of medical materials stimulating recovery of bone tissue defects, including in dentistry, and as sorbents for adsorption of heavy metal ions. For production of monophase nano crystalline calcium-deficient hydroxyapatite carbonate containing Ca_10-d(PO₄)_6-x(CO₃)_x(OH)_2+x-2d, where d is degree of deficiency of Ca²⁺, and x is degree of CO₃ ^2- substitution, which value is not lower than 0.76, but not higher than 1.21, aqueous solution of calcium hydroxide/ammonium carbonate composition using 0.08-0.16 % of calcium hydroxide aqueous solution. To said solution after mixing for 10-15 minutes and settling until complete dissolution of calcium hydroxide calculated amount of ammonium carbonate is added to obtain ready product with weight content of carbonate ions from 5 to 8 wt% and molar ratio of Ca/(P+CO₃ ^2-) below 1.67. Then to composition of calcium hydroxide/ammonium carbonate 10-20 % solution of orthophosphoric acid is added at a rate of 0.5-5 ml/min per litre of water solution of calcium hydroxide/ammonium carbonate composition under condition of maintaining reaction mixture pH higher than 11. One performs settling for completion of phase formation process, extraction and drying precipitate. After product drying to constant mass it undergoes grinding.

EFFECT: invention enables to obtain nano sized product with high bioactivity with average crystal size from 8 to 70 nm, specific surface area of 90-200 m²/g and sorption capacity to heavy metal ions to 1,720 mg/g.

1 cl, 3 dwg, 4 tbl, 7 ex