METHOD OF PRODUCING 2-(2-AMINO)ALKYLADAMANTANES Russian patent published in 2013 - IPC C07C209/44 C07C211/19 C07C213/02 C07C215/42 

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of adamantane derivatives, particularly an improved method of producing 2-(2-amino)alkyladamantanes of general formula (I), which can be of interest as intermediate products in synthesis of certain biologically active substances. The method of producing 2-(2-amino)alkyladamantanes of general formula (I): , where X=H, OH; R=H, CH₃, C₂H₅, involves reducing 2-adamantylene acetonitrile with active hydrogen formed by reacting potassium hydroxide with aluminium contained in a nickel-aluminium (50/50) Raney alloy, with molar ratio of nitrile to hydrogen of 1:5-10. Reduction is carried out in a water-tetrahydrofuran medium.

EFFECT: method increases technological effectiveness of synthesis by changing conditions for implementing the method, enables to obtain a wider range of 2-(2-amino)alkyladamantane derivatives and also increases output of products to 90-96% and purity thereof.

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