FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of N-(1-adamantylalkyl)cycloalkylamines of general formula:
,
1: X=- single bond, Z is cyclopentyl; 2: X=-CH2-, Z-cyclopentyl; 3: X=-CH-CH3, Z-cyclopentyl; 4: X=-CH-CH3, Z-cyclohexyl. Method involves reacting amino derivatives of adamantane with corresponding cyclic alcohols (cyclopentanol and cyclohexanol) in the presence of a Raney-Ni catalyst. The reaction is carried out in 8-16 hours with molar ratio of catalyst: adamantane-containing amine: alcohol equal to 0.21-0.6:1:6-14.8, which enables to obtain desired products in a single step with high selectivity and output of 53-91%.
EFFECT: improved method.
4 ex
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