HETEROCYCLIC COMPOUNDS OF BENZODIOXOL OR BENZODIOXEPIN AS INHIBITORS OF PHOSPHODIESTERASES Russian patent published in 2016 - IPC C07D493/00 C07D495/10 A61K31/443 A61K31/4433 A61K31/4436 A61P11/00 A61P17/00 A61P9/00 A61P25/00 A61P35/00 A61P37/00

Abstract RU 2583787 C2

FIELD: bioengineering.

SUBSTANCE: invention relates to the new compounds of the common formula where each of m and n independently discloses 0 or 1; R₁ and R₂, together with a carbon atom whereto these are connected to make a heterocyclic ring containing one or two heteroatoms selected from oxygen, sulphur, -S(O)- and -S(O)₂-; R₃ stands for -CHF₂, -CF₃, -OCHF₂, -OCF₃, -SCHF₂ or -SCF₃; or their pharmaceutically acceptable salts, hydrates or solvates. Besides, it relates to pharmaceutical compositions based thereon and to the treatment of inflammation.

EFFECT: active inhibition of PDF4, efficient treatment of inflammation.

28 cl, 1 tbl, 15 ex

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RU 2 583 787 C2

Authors

Nilsen Simon Feldbek

Dates

2016-05-10—Published

2011-06-24—Filed