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2 495 048

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IPC

C07K14/775(2006-01-01)

A61K38/17(2006-01-01)

A61P9/10(2006-01-01)

(21) (22)

Application

2012115397/04, 2012-04-18

(24)

Start date

2012-04-18

(22)

Actual filing date

2012-04-18

(45)

Published

2013-10-10

(72)

Inventor

Isaev Andrej ValentinovichKetlinskij Sergej AleksandrovichSimbirtsev Andrej SemenovichPetrov Aleksandr VladimirovichKolobov Aleksandr AleksandrovichPrusakov Aleksej NikolaevichSineva Svetlana AdamovnaVarjushina Elena Anatol'EvnaAleksandrov Georgij Vjacheslavovich

(73)

Holder

Isaev Andrej ValentinovichKetlinskij Sergej AleksandrovichSimbirtsev Andrej Semenovich

PEPTIDE POSSESSING ANTIATHEROSCLEROTIC ACTION AND COMPOSITION FOR PREVENTING AND TREATING ATHEROSCLEROTIC VASCULAR DISEASE Russian patent published in 2013 - IPC C07K14/775 A61K38/17 A61P9/10

Abstract RU 2495048 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to immunology and medicine, namely to new peptides of general formula: X-CC-C(Y)-CC-Z, wherein X is a B-cell epitope of apolipoprotein B100 protein; C is an amino acid residue specified in K or R; Y is an immunoadjuvant specified in a group of Pam₁CSS-; Pam₂CSS-, Pam₃CSS-; Z - T-helper epitope specified in AKFVAAWTLKAAA, KLIPNASLIENCTKAEL, QYIKANSKFIGITE.

EFFECT: peptide preparations possess higher antisclerotic activity as compared to their analogues, and the compositions thereof are of practical interest as a vaccine for preventing and treating atherosclerotic vascular disease.

9 cl, 1 dwg, 6 tbl, 7 ex

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RU 2 495 048 C1

Authors

Isaev Andrej Valentinovich

Ketlinskij Sergej Aleksandrovich

Simbirtsev Andrej Semenovich

Petrov Aleksandr Vladimirovich

Kolobov Aleksandr Aleksandrovich

Prusakov Aleksej Nikolaevich

Sineva Svetlana Adamovna

Varjushina Elena Anatol'Evna

Aleksandrov Georgij Vjacheslavovich

Dates

2013-10-10—Published

2012-04-18—Filed