METHOD FOR ASSESSING ANTISMALLPOX ACTIVITY OF THERAPEUTIC PREPARATIONS Russian patent published in 2013 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: for the purpose of assessing antismallpox activity of therapeutic preparations, a suspension of the above preparation is introduced into the reference and test groups of 8-15-day scrub heterosexual ICR mice of 9-11 g. That is followed by intranasal infection with the monkey pox virus strain V79-1-005. The strain is deposited in the State Collection of the Agents of Viral Infections and Rickettsial Diseases of the Federal State-Funded Institution of Science State Research Centre for Virology and Biotechnology "Vector", registration No V-309. The animal's lung virus concentration is determined to calculate estimated figures (indices) that are used to assess antiviral activity of the preparation. The assessed preparation is administered into mice one day before the infection, on the day of infection and then daily during a period of virus incubation in the animal's body.

EFFECT: method provides the model of the disease adequate to the clinical manifestations in a human, and the effective assessment of activity of the preparations ensured by creating the environment of the highest virus virulence in the animal selected for the experiment, having the highest consistence with the human primary target organs.

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