METHOD OF EVALUATION OF ANTIVARIOLIC ACTIVITY OF THERAPEUTIC AND PROPHYLACTIC PREPARATIONS Russian patent published in 2014 - IPC C12N7/00 A61K35/76 A61K39/275 A61P31/20 

FIELD: veterinary medicine.

SUBSTANCE: method of evaluation of antivariolic activity of therapeutic and prophylactic preparations comprises administering to the body of the animal model of control and test groups in a predetermined scheme of suspension of investigational antiviral preparation. Their intranasal infection is carried out with the strain of monkeypox virus, followed by incubation of the virus in animal bodies. The concentration of virus in the lungs of animals is determined, followed by the calculation of estimated indicators. The animal model is used as ordinary steppe heterosexual marmots Marmota bobak of 1-2-year-old age. The strain of monkeypox virus the strain of monkeypox virus V79-1-005 is used, deposited in the State collection of causative agents of viral infections and rickettsial diseases of the Federal budget institution of science State Research Centre of Virology and Biotechnology "Vector" under the registration number V-309.

EFFECT: invention enables to evaluate more adequately the activity of therapeutic antivariolic preparations and vaccines.

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