POLYMER SYSTEMS OF DELIVERING ACTIVE SUBSTANCES Russian patent published in 2014 - IPC C08L87/00 C08G73/00 A61P35/00 A61K31/337 A61K38/13 

Abstract RU 2523714 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compositions, containing an active substance. Described is a composition for the active substance delivery, which contains: a) at least, one block-copolymer, containing, at least, one poly(2-oxazoline) block A, consisting of repeating units of formula where RA stands for a hydrocarbon group, which can be optionally substituted with -OH, -SH, -COOH, -NR'2, -COOR', -CONR', -CHO, where R' stands for H or C1-3 alkyl, and RA is selected in such a way that a repeating link of formula (I) is hydrophilic; and at least one poly(2-oxazoline) block B, consisting of repeating units of formula (II), where RB stands for a hydrocarbon group, which can be optionally substituted with halogen, -OH, -SH, -COOH, -NR''2, -COOR'', -CONR'', -CHO, where R'' stands for H, alkyl or alkenyl, and RB is selected in such a way that a repeating link of formula is more hydrophobic than the repeating link of formula (I); and (b) one or more active substances. Also described is application of a copolymer for solubilisation of the active substance in water or a water solution.

EFFECT: described copolymers serve as a universal medication delivery system with high loading.

12 cl, 6 dwg

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RU 2 523 714 C2

Authors

Kabanov Aleksandr V.

Jordan Rajner

Ljuksenkhofer Robert

Dates

2014-07-20Published

2009-06-26Filed