POLYMER SYSTEMS OF DELIVERING ACTIVE SUBSTANCES Russian patent published in 2014 - IPC C08L87/00 C08G73/00 A61P35/00 A61K31/337 A61K38/13 

FIELD: chemistry.

SUBSTANCE: invention relates to compositions, containing an active substance. Described is a composition for the active substance delivery, which contains: a) at least, one block-copolymer, containing, at least, one poly(2-oxazoline) block A, consisting of repeating units of formula where R^A stands for a hydrocarbon group, which can be optionally substituted with -OH, -SH, -COOH, -NR'₂, -COOR', -CONR', -CHO, where R' stands for H or C_1-3 alkyl, and R^A is selected in such a way that a repeating link of formula (I) is hydrophilic; and at least one poly(2-oxazoline) block B, consisting of repeating units of formula (II), where R^B stands for a hydrocarbon group, which can be optionally substituted with halogen, -OH, -SH, -COOH, -NR''₂, -COOR'', -CONR'', -CHO, where R'' stands for H, alkyl or alkenyl, and R^B is selected in such a way that a repeating link of formula is more hydrophobic than the repeating link of formula (I); and (b) one or more active substances. Also described is application of a copolymer for solubilisation of the active substance in water or a water solution.

EFFECT: described copolymers serve as a universal medication delivery system with high loading.

12 cl, 6 dwg