FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry. A pelletised form of amison contains the active substance amison-N-methyl-4-benzylcarbamidopyridinium iodide, as an excipient - lactose, basic magnesium carbonate, or dibasic calcium phosphate, or pre-gelled starch, and also microcrystalline cellulose, as binding agents - saccharose and povidone, as an anti-cleavage agent - copolyvidone, as a desintegrant - crospovidone or sodium croscarmellose and as sliding agents - stearic acid, and/or a calcium stearate, and/or magnesium stearate. An amison pellet can be film-coated. The amison pellet is prepared by wet granulation.
EFFECT: amison pellets under the invention are characterised by high fracture and abrasion strength and have no cleavages.
6 cl, 1 tbl
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Authors
Dates
2012-05-10—Published
2010-08-27—Filed