FIELD: biotechnologies.
SUBSTANCE: nucleic acid molecule codes a polypeptide consisting of two residues of methionine as the first and the second N-end amino-acid residues connected through a peptide link to a mature eucariotic histone. Polypeptide is obtained by cultivation of a host cell transformed by an expression vector including the above molecule of nucleic acid. Polypeptide is used as part of pharmaceutical composition for therapy of cancer, bacterial, virus or fusarium infections. Besides, polypeptide is used as part of composition for diagnostics of a patient in relation to response to pharmaceutical composition containing the above polypeptide, or in relation to curability using it.
EFFECT: invention allows improving efficiency of recombinant expression and simplifying determination of the above polypeptide in presence of endogenic histones at preservation of biologic activity of mature eucariotic histone.
17 cl, 3 dwg, 6 tbl, 7 ex
| Title |
Year |
Author |
Number |
| BIS-MET-HISTONES |
2008 |
- Tiri Mishel
- Gross Peter
- Jernvall Khans
- Formika-Tseppetsauer Gratsina
- Tseppetsauer Mikhel
|
RU2640247C2 |
| PHARMACEUTICAL ANTITUMORAL COMPOSITION OF PACLITAXEL WITH HISTONE N1.3 AS A CARRIER AND A METHOD FOR PREPARING THE COMPOSITION |
2017 |
- Chasov Vitalij Vasilevich
- Rizvanov Albert Anatolevich
- Cheremin Andrej Mikhajlovich
- Akhatova Farida Serikovna
- Danilushkina Anna Aleksandrovna
|
RU2669937C1 |
| POLYPEPTIDES DERIVED FROM TRYPTOPHANYL-TRNA-SYNTHETASE AND USES THEREOF IN CONTROLLING OF VASCULARISATION |
2002 |
- Shimmel' Pol
- Vakasugi Kejsuke
- Frehdlehnder Martin
|
RU2297425C2 |
| HGF BETA-CHAIN VERSIONS |
2006 |
- Kirkkhofer Dehniel K.
- Lazarus Robert Eh.
- Vismann Kristian
|
RU2403261C2 |
| AXM1554 GENE ENCODING DELTA-ENDOTOXIN AND METHODS FOR ITS APPLICATION |
2016 |
- Rodzhers-Viejra Eliz
- Sempson Kimberli
- Lekhtinen Duejn
- Lezel Peter
- Portts Daniela
- Chkhougule Nanasakheb
|
RU2755282C2 |
| RECOVERED PEPTIDE EXHIBITING SPECIFIC ANTI-GDF-8 ANTIBODY BINDING ACTIVITY, RECOVERED NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, HOST CELL, METHOD FOR PRODUCING PEPTIDE, VACCINE COMPOSITION AND METHOD OF ELICITING ANTI-GDF-8 IMMUNE RESPONSE, METHOD OF ANTI-GDF-8 ANTIBODY SELECTION SCREENING AND METHOD OF GDF-8 ACTIVITY DOWN-REGULATION IN ANIMAL |
2004 |
- Dzhanker Dehvid Eh.
- Kokhrehn Mark D.
|
RU2422460C2 |
| METHODS AND COMPOSITIONS FOR ACTIVATION MODULATION OF HEPATOCYTE GROWTH FACTOR |
2005 |
- Kirkhkhofer Dehniel K.
- Moran Pol M.
- Pik Mark D.
|
RU2405041C2 |
| MODIFIED INTERLEUKIN-7 PROTEIN AND METHODS FOR USE THEREOF |
2016 |
- Yang, Se Hwan
- Choi, Donghoon
- Lim, Hye Seong
|
RU2708160C2 |
| ISOLATED NUCLEIC ACID, ENCODING OPERATIVELY FUSED INTRAMOLECULAR DIMER OF KillerRed PROTEIN, EXPRESSION CASSETTE, CELL, WHICH PRODUCES CHIMERIC PROTEIN AND CONTAINS EXPRESSION CASSETTE, ISOLATED CHIMERIC PROTEIN |
2011 |
- Luk'Janov Konstantin Anatol'Evich
- Serebrovskaja Ekaterina Olegovna
- Luk'Janov Sergej Anatol'Evich
|
RU2491342C1 |
| ISOLATED KillerRed PROTEIN-CODING NUCLEIC ACID (VERSIONS), ISOLATED PROTEIN (VERSIONS), EXPRESSION CASSETTE, CELL CONTAINING EXPRESSION CASSETTE |
2011 |
- Luk'Janov Konstantin Anatol'Evich
- Serebrovskaja Ekaterina Olegovna
- Luk'Janov Sergej Anatol'Evich
|
RU2458129C1 |
