ORALLY DISPERSIBLE MANNITOL Russian patent published in 2013 - IPC A61K9/16 A61K9/20 A61K47/10 A61K47/26 A61J3/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to co-agglomerates of mannitol with an average volumetric diameter of 1-200 mcm, and granulated starch, to be applicable as binding substances and disintegrants for preparing orally dispersible tablets. The mannitol/starch relation makes 90/10-50/50, and the co-agglomerates have the average volumetric diameter of 60-500 mcm; a time of relaxation is 30 to 100 seconds, while a swelling intensity makes 0.8 to 3.0 H. The invention also refers to a method for preparing the above co-agglomerates which involves preparing a suspension of crystalline mannitol and granulated starch at temperature 15-25°C, keeping the above suspension at temperature 15-25°C and spraying the above suspension in a MSD-type spray tower equipped with a pressure oil atomizer with fine particles re-injection into a head end of the spray tower, and separating the prepared co-agglomerates from mannitol and starch.

EFFECT: invention refers to the orally dispersible tablet which contains the co-agglomerates of mannitol and starch as a binding substance and a disintegrant, and an active agent.

13 cl, 10 tbl, 5 ex