NOVEL PYRROLE DERIVATIVE HAVING AS SUBSTITUTES UREIDE GROUP, AMINOCARBONYL GROUP AND BICYCLIC GROUP, OPTIONALLY SUBSTITUTED Russian patent published in 2013 - IPC C07D207/34 C07D403/04 C07D405/04 C07D409/04 C07D413/04 C07D417/04 A61K31/40 A61K31/4025 A61K31/404 A61P27/02 

Abstract RU 2500669 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel pyrrole derivatives of the formula (1): or pharmaceutically acceptable salts thereof, where: R1 denotes H, halogen; R2 denotes an 8-10-member bicyclic hydrocarbon group, optionally substituted, or a bicyclic heterocyclic group consisting of one or two atoms selected from nitrogen, oxygen and sulphur and 5-9 carbon atoms, optionally substituted, where the optional substitute is halogen, lower alkyl, OH, lower alkoxy, oxo, NO2, CN; R3 denotes H.

EFFECT: compounds have inhibiting action of production of IL-6, which enables use thereof in a pharmaceutical composition and when treating a range of diseases.

12 cl, 1 tbl, 10 ex

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RU 2 500 669 C2

Authors

Kavasima Kendzi

Kavasima Noriko

Enomoto Khirosi

Jamamoto Minoru

Mjurai Masaaki

Dates

2013-12-10Published

2009-08-25Filed