FIELD: chemistry.
SUBSTANCE: invention relates to novel indole derivatives containing a carbamoyl group, a ureide group and a substituted oxy group or to pharmaceutically acceptable salts, having general formula
,
where values of R1-R3, m are given in claim 1.
EFFECT: compounds exhibit inhibiting activity on IKKβ, which enables use thereof as a preventive or therapeutic agent for treating several diseases associated with IKKβ.
25 cl, 1 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL PYRROLE DERIVATIVE HAVING AS SUBSTITUTES UREIDE GROUP, AMINOCARBONYL GROUP AND BICYCLIC GROUP, OPTIONALLY SUBSTITUTED | 2009 |
|
RU2500669C2 |
| NOVEL INDOLE DERIVATIVES HAVING IκB KINASE β INHIBITING ACTIVITY | 2008 |
|
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| INDOLOPYRROLOCARBAZOLE DERIVATIVES AND METHODS OF PREPARATION THEREOF | 1992 |
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| AMIDES OF ACIDS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
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| INHIBITOR OF INTEGRIN EXPRESSION | 2001 |
|
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| SULFONAMIDE GROUPS-CONTAINING HETEROCYCLIC COMPOUND, INTERMEDIATE COMPOUND AND ANTI-ANGIOGENIC AGENT BASED ON THEREOF | 2000 |
|
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| PYRROLOINDOLES, PYRIDINEINDOLES AND AZEPINOINDOLES AS 5-HT AGONISTS | 1999 |
|
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| SUBSTITUTED INDOLES, ANTIVIRAL ACTIVE COMPONENT, SYNTHESIS AND APPLICATION METHOD | 2010 |
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| PERI-SUBSTITUTED ARYLSULPHONAMIDE BICYCLIC COMPOUNDS FOR TREATING ARTERY OCCLUSIVE DISEASES | 2005 |
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| DERIVATIVES OF AROMATIC AMINES ELICITING EFFECT INHIBITING OAC, METHOD OF THEIR SYNTHESIS AND INHIBITOR OF нOAC | 1997 |
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